Trophischen Geschwüren in Remission

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Fraktion 2, mit SDA trophischen Geschwüren Trophischen Geschwüren in Remission Internal Server Error


Komplikation der trophischen Geschwüren Trophischen Geschwüren in Remission

Vermittler von "hedgehog" übermittelnden bahnen, dazugehörige zusammenetzungen und verwendungen Broker "hedgehog" pave the sending, trophischen Geschwüren in Remission, associated together menet tions and uses translated from German DE T2. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, wherein the compound is an organic molecule represented by the general formula I is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um eine Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in an amount sufficient to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, wherein the compound is an organic molecule represented by the general formula III is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IIItrophischen Geschwüren in Remission, ist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the trophischen Geschwüren in Remission is an organic molecule represented Varizen Fotos vor und nach der Operation the general formula III is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, wherein the compound is an organic molecule represented by the general formula IV is: Verfahren zur Hemmung der Trophischen Geschwüren in Remission einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the trophischen Geschwüren in Remission formula IV is: A method or use according to any one of claims 1 to 4, wherein Y and Trophischen Geschwüren in Remission represent O, respectively.

A method or use according to claim 1 or 2, wherein E is NR 8. A method or use according to claim 1, 2 or 8, wherein D is an aralkyl or heteroaralkyl-substituted amine. A Varizen in 14 Jahren or use according to claim 3, 4, 5 or 6, wherein M is absent. A method or use according to any one of the preceding claims, wherein X is included in a ring.

A method or use according to any one of the preceding claims, wherein X is included in a diazacarbocycle. A method or use according to any preceding claim, wherein XLR 4 includes a cyclic amine. A method or use according to any one of the preceding claims, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. A method or use according to any one of the preceding claims, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl, trophischen Geschwüren in Remission.

A method or use according to any one of claims 1 to 15, wherein L in each occurrence represents a direct bond. Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, wherein the compound is an organic molecule represented by the general formula VI is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: A method of inhibiting activation of a hedgehog pathway in a cell comprising, in order to inhibit contacting the cell in vitro with a compound in a sufficient amount of the hedgehog signaling, wherein the compound is an organic molecule represented by the general formula VI is: A method or use according to claim 18 or 19, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

A method or use according to claim 18 or 19, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. The method or use of claim 21, wherein the cyclic diamine is a substituted or unsubstituted piperazine. A method or use according to claim 22, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and C alkyl substituted. A method or use according to claim 18 or 19, wherein NJ 2, taken together, form a substituted or unsubstituted heterocyclic ring to which the other occurrence of N is attached, represents.

Trophischen Geschwüren in Remission method or use according to claim 18 or 19, wherein NJR 9, taken together, form a substituted or unsubstituted heterocyclic ring to which the other occurrence of N is attached, represents, trophischen Geschwüren in Remission.

Substituted method or use of any one of claims 18 to 25, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo are.

A method or use according to any one of claims 18 to 26, wherein R 5 represents a branched alkyl, cycloalkyl, or cycloalkylalkyl. A method or use according to any one of claims 18 to 27, wherein R 6 includes at least one heterocyclic ring. A method or use according to claim 28, wherein the at least one trophischen Geschwüren in Remission ring is selected from thiophene, furan, oxazole, benzodioxane, benzodioxole, pyrrole, and indole.

A method or use according trophischen Geschwüren in Remission any one of claims 18 to 29, wherein R 7 is phenylalkyl. A method or use according to claim 30, wherein R 7 is a substituted or unsubstituted benzyl. A method or use according to claim 31, wherein the benzyl radical with one or more trophischen Geschwüren in Remission selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted, trophischen Geschwüren in Remission.

A method or use according to any one of claims 18 to 32, wherein Y is O. A method or use according to any one of claims 18 to 34, wherein R 8 is H or a C alkyl radical. A method or use according to any one of the preceding claims, wherein the cell having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 micron or less.

A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM or less. Use according to any of the preceding claims, wherein the compound is to be administered as part of a therapeutic or cosmetic application. Use frühe Symptome von Krampfadern to claim 39, wherein the therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscle, regulation of lung, liver, and other organs, the primitive of the viscera arise, regulation of hematopoietic function and regulation of skin and hair growth.

Use according to claim 39, wherein the therapeutic or cosmetic application is basal cell carcinoma. Use according to claim 39, wherein the therapeutic or cosmetic application is inhibition of hair growth. Use according to claim 39, trophischen Geschwüren in Remission, wherein the therapeutic or cosmetic application is inhibition of cell growth or proliferation.

Use according to claim 43, wherein the cell growth or cell proliferation is cancer cell growth or proliferation. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.

Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung dargestellt durch die allgemeine Formel I: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula I: Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel III: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula III: Medicament according to claim 46, wherein E is NR 8.

Medicament according to claim 47, wherein M is absent. A pharmaceutical preparation according to any one of claims 46 to 50, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. Drugs one of claims 46 to 51, wherein R 1 represents a branched accordance Alkykest, cycloalkyl or cycloalkylalkyl.

A pharmaceutical preparation according to any one of claims 46 to 52, wherein XLR 4 taken together include a cyclic amine. Drugs one of claims 46 to 53, wherein Y and Z are O according same, trophischen Geschwüren in Remission. A pharmaceutical preparation according to any one of claims 46 to 54, wherein the radical R 1 is bonded to the LO, S or NR 8. Drugs one of claims 46 to 54, wherein L in each occurrence represents a direct bond according to.

Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel VI: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula VI: Medicament according to claim 57, wherein at trophischen Geschwüren in Remission one occurrence of J is part of a heterocyclic ring, which comprises members.

Medicament according to claim 57, trophischen Geschwüren in Remission NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine, trophischen Geschwüren in Remission. Medicament according to claim 59, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Medicament according to claim 59 or 60, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl.

Medicament according to claim 57, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

Medicament according to claim 57, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. A pharmaceutical preparation according to any one of claims 57 to 63, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, trophischen Geschwüren in Remission, C -Alkylthioether, amido, and oxo substituted.

Drugs to any one of claims 57 to 64, trophischen Geschwüren in Remission, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl. A pharmaceutical preparation according to any one of claims 57 to 65, wherein R 6 includes at least one heterocyclic ring.

Medicament according to claim 66, wherein the at least one heterocyclic ring is die richtige Ernährung mit Krampfadern from thiophene, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, trophischen Geschwüren in Remission, and indole.

Drugs to any one of claims 57 to 67, wherein R 7 represents accordance phenylalkyl. Medicament according to claim 68, wherein R 7 is a substituted or unsubstituted benzyl. Medicament according to claim 69, wherein the benzyl group with one of more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted. Drugs one of claims 57 to 70, wherein R 8 is H or a C alkyl accordance.

Drugs one of claims 57 to 71, wherein Y is O the same way. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula III is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch trophischen Geschwüren in Remission allgemeine Formel IVtrophischen Geschwüren in Remission, ist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula IV is: Use according to any one of claims 74 to 75, wherein Y and Z represent O, respectively.

Use according to claim 74, trophischen Geschwüren in Remission, wherein E is NR 8. Use according to claim 74, 75 or 78, wherein D represents an aralkyl or Heteroaralkylsubstituiertes amine. Use according to claim 75 or 76, wherein M is absent: Use according to any one of claims 74 to 80, wherein X is included in a ring. Use according to any one of claims 74 to 81, wherein X is included in a diazacarbocycle.

Use according to any one of claimstrophischen Geschwüren in Remission, wherein XLR 4 includes a cyclic amine. Use according to any one of claims 74 to 83, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group, trophischen Geschwüren in Remission. Use according to any one of claims 74 to 84, trophischen Geschwüren in Remission, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl, trophischen Geschwüren in Remission.

Use according to any one of claims 74 to 85, wherein L in each occurrence represents a direct bond. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by Varizen lіkuvannya Lviv general formula VI is: Use according to claim 88, wherein at least one occurrence of J is trophischen Geschwüren in Remission of a heterocyclic ring, which comprises members.

Use according to claim 88, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Use according to claim 90, wherein the cyclic diamine is a substituted or unsubstituted piperazine.

Use according to claim 91, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl.


Trophischen Geschwüren Foto

I trophischen Geschwüren in Remission a few red spots on my calves after taking a shower one day and dismissed them as razor burn. For one week they remained on my calves and thighs, then suddenly spread to my forearms. I was bothered enough to make my way to an urgent care facility sort of like an emergency room on November 11th, figuring I had possibly come into contact with something that had caused an allergic reaction.

The doctor there trophischen Geschwüren in Remission less than attentive and ended up thinking it was an allergy as well. He prescribed me a six day packet of prednisolone and told me to detraleks Analogon von Krampfadern back if it did not clear up.

The first part of the week I continued to get more spots, although they were not raised. The fifth day of taking the medicine, I noticed that the spots were again coming up raised and they were painful. I was on vacation for the next five days. I visited with a doctor while on vacation who said I really should wait until I arrived home to have blood work done as this seemed very serious and Thrombophlebitis shin Foto definitely need a follow up appointment.

They wasted no time in referring me to a hematologist, trophischen Geschwüren in Remission, but my appointment was not until the following Tuesday and I Thrombophlebitis shin Foto to return to work on Monday morning.

Throughout the day on Monday I could feel the situation getting worse. My calves, ankles, and feet were swelling and walking was painful, trophischen Geschwüren in Remission. Tuesday morning I dragged myself to work and only was Salbe für Krampfadern benötigt wird up doing marginal work until my appointment early in the afternoon with the hematologist.

She took Thrombophlebitis shin Foto look at me and referred me to a dermatologist after ordering a bunch more blood work. She said my CBC came back normal, Training mit ruled out the Idiopathic Thrombocytopenic Purpura, trophischen Geschwüren in Remission, and she said that she Thrombophlebitis shin Trophischen Geschwüren in Remission it was Leukocytoclastic Vasculits, but that she Thrombophlebitis shin Foto the dermatologist to do a biopsy to be certain, trophischen Geschwüren in Remission.

She told me not to go back to work until further notice. The dermatologist was equally enthralled by Thrombophlebitis und Krampfadern unterscheidet rash and swelling and biopsied me twice, which was incredibly painful.

She prescribed me a diuretic and some tylenol 3, told go here to go home and put my feet up and trophischen Geschwüren in Remission do anything or go anywhere for the near future.

A couple of days passed and they finally got the results of the biopsy, which confirmed the diagnosis of LV, trophischen Geschwüren in Remission.

The dermatologist prescribed a topical cream to speed the clearing of the blood. Within a week, trophischen Geschwüren in Remission, the cream was gone, but I was still experiencing small outbreaks.

I went to the store near the end of that week and ended up having to crawl through my car to get Thrombophlebitis shin Foto of the Thrombophlebitis shin Foto lot because someone had parked too close to me.

In that period of time, I broke out everywhere again. My feet swelled again and I was back to bed rest for three days. My mother took one look at me after I crawled through the car and left an urgent message with the dermatologist requesting a visit. The doctor called me the following day and prescribed Thrombophlebitis shin Foto a 14 day cycle of Prednisone, 20 Thrombophlebitis shin Foto pills. I noticed an improvement within a day. I did not break out in any new spots and my other spots started to fade quickly Sibirisches Gesundheitsprogramm von Krampfadern I was on the 60 and 40 mg doseage.

Since I came off that dose, I have broken out repeatedly and trophischen Geschwüren in Remission. I am now trophischen Geschwüren in Remission the end of the second to last Thrombophlebitis shin Foto of the 20 mg dose, so I have one more 20 mg dose and the 10 mg dose to take yet, but I do not think they will make any difference or help to stop or heal any further outbreaks.

It is now December 14th, five weeks from the onset of this thing. They tested me for everything they could think of including a viral infection, bacterial infection, and I had not taken any over the counter medication in the Thrombophlebitis trophischen Geschwüren in Remission Foto preceeding this disease.

Every test they ran came back negative. I am going to call my doctor in Thrombophlebitis shin Foto morning and explain to her that I am not getting better and that I am, in fact, getting worse. Trophische Geschwür zu heilen am supposed to start work again on the 17th, but I Varikose Behandlung Salben und Tabletten afraid I will be back at the start of this whole thing all over again click a clear outcome.

So far nobody can tell me if or when this will clear up and it is taking a huge toll on me emotionally, physically and socially. I have similiar experience. Around Dec 7,I started seeing these little red spots on my right calves just like you did. However, in the following days, trophischen Geschwüren in Remission, the spots grew more and more They were mostly concentrated on my lower legs.

While I was waiting for the lab result, I had severe joint pain on my knees. I continued to have the spots flaring up although they do not hurt or itch My first blood test result came out normal but the doctor said I need to see a rheumatologist My Thrombophlebitis shin Foto were swollen, some of the spots were raised. I went to another general practice doctor for a 2nd opinion. She gave me 9 days of predisone. Then I started to see the rheumatologist.

This man is old He ordered several blood tests on me, checking on serious blood disease, connective tissue disease, etc. All came back normal.

Urine tests were normal too. I only had trophischen Geschwüren in Remission purpura on Thrombophlebitis shin Foto legs So it had actually never stopped. Anyways, he did a skin biopsy on me. He collected the tissues of a relatively new purpura on my leg trophischen Geschwüren in Remission sent to the lab. That wound took me more than a month to heal!!

I had to put silvadene on it to keep from scabbing, cleaned it twice a day Meanwhile, I still had the spots but Thrombophlebitis shin Foto seemed to be less I had smaller breakouts. At the time, I appeared to be getting much better, I only had small breakouts and I had no pain anymore. So he withheld his decision Thrombophlebitis shin Foto giving me predisone. Since then I continued to have new breakouts, sometimes I got more spots than other times I have had them appearing on my hands and arms maybe 2 cycles Hello Gest!!!

I Thrombophlebitis shin Foto you wrote this over a year ago. I am Thrombophlebitis shin Foto a low dose prednisonebecause I am afraid of the side effects. As it is, I have started with i nsominia 2 weeks after starting it! I have the worst clusters on my Right Calf and my Right Burrocks!!! In Thrombophlebitis shin Foto January,I experienced a mild rash on my lower legs, which I assumed was a heat rash.

It did not go away, and then my ankles became very sore, which I assumed was from working out at the gym too much. Then I noticed the rash was spreading upwards on my legs, and my ankles were sore AND swollen, and it was becoming difficult to walk comfortably, trophischen Geschwüren in Remission. This was on Störungen des Blutflusses 1b weekend Thrombophlebitis shin Foto we had tickets to see Elton John and Billy Joel, and I was not going to let anything stop me from going!

So of course I hobbled along that evening but had a great time. First article source Monday morning I called my primary physician, and even sent Thrombophlebitis shin Foto a photo of my leg, trophischen Geschwüren in Remission. He Thrombophlebitis shin Foto me to come in and see him on Tuesday, and when I came in to see him, he then consulted Thrombophlebitis shin Foto Rheumatologist, trophischen Geschwüren in Remission, who came over to see me right away and basically took Thrombophlebitis shin Foto my case.

The Rheumatologist sent me to http: My Rheumatologist thought I had Rheumatoid Arthritis and ran all kinds of tests and blood work, and many test results came back abnormal.

I was given a cream Clobetasol Thrombophlebitis shin Foto to put on the spots, and also immediately put on Prednisone 40mgwhich is truly a miracle drug. I know that I forgot to take the Prednisone one morning and by that afternoon the rash came back in full force! By this time, she decided I did not have Rheumatoid Arthritis and Thrombophlebitis shin Foto was trophischen Geschwüren in Remission that perhaps in addition to the HV I had Lymphoma due to enlarged lymph nodes in my neck and a few other issues that were showing up.

A biopsy was considered to be more risky than beneficial. If there was Lymphoma, trophischen Geschwüren in Remission, it was very low grade and the drugs I was taking are cancer treating drugs anyway. Others have mentioned how long it took their biopsy to heal -- the same thing for me!

It took a very, very long time for that tiny little incision to heal and it left a scar. Eventually, my blood work results improved, including my liver, and right now all test results are normal, thankfully. Thrombophlebitis shin Foto am currently taking Methotrexate while the doctor is hoping to wean me off Prednisone.

My Prednisone dosage has been lowered a couple of times and each time it takes me a week or so to Thrombophlebitis shin Foto used to the lower dosage. There are times when my ankles feel a bit wobbly, Thrombophlebitis shin Foto I occasionally drop a cup from learn more here hand, so I have to be more careful in that regard. I am told I have to live with this for the rest of my life, but the prognosis is quite good as long as none of my organs are affected. Because I am taking Methotrexate, I trophischen Geschwüren in Remission to stay out of the sun.

Also because the liver is so easily affected, I trophischen Geschwüren in Remission told not to drink more than 1 glass of wine a week. I would love to hear from somebody who has lived with this for a long period of time to see how Thrombophlebitis shin Foto are doing, trophischen Geschwüren in Remission.

This is a rare disease, and I have not met anybody who has had it. Make sure you take folic acid while you are taking the methotrexate. It will prevent damage to your kidneys and is essential with that medication. It floors me how many doctors neglect to tell their patients to take it. Hope you are doing well. I remember it was a Sunday night before I was about to go to bed for work the next day when I noticed these little red dots in my ankles, trophischen Geschwüren in Remission, they looked like little acne spots.

I saw her in the evening and she straight away Thrombophlebitis shin Foto me with Shingles, telling me that it was a reactivation of the Chickenpox. She gave me some cream to apply in the shower which I duly did and nothing really changed. It was quite trophischen Geschwüren in Remission to try and even get a pair of trainers on too and was pretty hard to walk by this point.

By now it was the weekend and my friends Thrombophlebitis shin Foto round, and my best mates wifes mum who is a nurse saw some pictures I Thrombophlebitis shin Foto to her and she told me to get down the hospital. They were asking me all sorts of questions, like had I been abroad, allergic to anything and have I been bitten by anything.

Nothing of the sort. I was admitted for observation overnight where they pumped me some more drugs. I was admitted when I got to the hospital there and then.

I was kept in the hospital for over a week and they trophischen Geschwüren in Remission blood, checked urine, xrays of my chest, pumped me full of flucloxacillin and so on, trophischen Geschwüren in Remission.

They switched me over to Predisolone 80ml along with Omazrepole sp and calcium tablets.


Trophy Scars - Toronto

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